英文字典中文字典


英文字典中文字典51ZiDian.com



中文字典辞典   英文字典 a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z       







请输入英文单字，中文词皆可：


请选择你想看的字典辞典：
单词字典翻译
sleppa查看　sleppa　在百度字典中的解释百度英翻中〔查看〕
sleppa查看　sleppa　在Google字典中的解释Google英翻中〔查看〕
sleppa查看　sleppa　在Yahoo字典中的解释Yahoo英翻中〔查看〕

安装中文字典英文字典查询工具!


中文字典英文字典工具:
选择颜色:
输入中英文单字

































































英文字典中文字典相关资料:


  • siRNA-mediated therapeutic approaches improve acute kidney injury and . . .
    This review provides an overview of siRNA-based therapeutics including the chemical modification of siRNA to enhance stability and reduce immunogenicity in drug development, the latest development of siRNA delivery systems to improve organ such as kidney targeting and cellular uptake, and the mechanism of siRNA-based RNAi in the pathogenesis of
  • Enhancing siRNA efficacy in vivo with extended nucleic acid . . . - Nature
    Therapeutic small interfering RNA (siRNA) requires sugar and backbone modifications to inhibit nuclease degradation However, metabolic stabilization by phosphorothioate (PS), the only backbone
  • Innate immune regulations and various siRNA modalities
    This review describes the various innovative siRNA therapeutics and their implications on the developed immune regulations to silence the disease effects Graphical Abstract siRNA causes the silencing effects through RISC processing The innate immune signalling is induced by both TLR-dependent and TLR-independent pathways
  • Small Interfering RNA in Kidney Diseases: Promises and Limitations - MDPI
    In this review, the biological mechanisms underlying the use of siRNAs are briefly exposed The results of the therapeutic application of RNA interference to the kidney and its diseases are also analyzed and discussed
  • siRNA Delivery In Vivo: Challenges and Strategies
    This mechanism allows nanoparticles, especially those smaller than 100 nm, to accumulate in tumors, hepatocytes, and inflamed tissues Strategies to reduce off-target gene silencing and immune responses involve careful siRNA design, chemical modifications, and specialized delivery systems that prevent non-specific interactions
  • Introducing an In Vitro Liver Stability Assay Capable of Predicting the . . .
    Basiri and colleagues have demonstrated that the stability of liver-targeting GalNAc-conjugated siRNAs in mouse liver homogenate shows an acceptable correlation to their in vivo target knockdown efficacy Therefore, they suggest the incorporation of an in vitro liver homogenate stability assay during the lead optimization process for siRNAs
  • A Comprehensive Review of Small Interfering RNAs (siRNAs): Mechanism . . .
    siRNA, when used as a therapeutic drug, faces challenges such as a short half-life, poor serum stability, and susceptibility to nuclease degradation Furthermore, its negative charge hinders easy entry into tumor cells through the cell membrane and is prone to degradation by intracellular lysosomes
  • Systematic analysis of siRNA and mRNA features impacting fully . . .
    Systematically defining the relative contributions of siRNA sequence, structure, and modification pattern versus the native context of the target mRNA is necessary to inform design considerations and facilitate the widespread application of this therapeutic platform
  • Knocking down disease: a progress report on siRNA therapeutics
    The challenges in turning ASOs into drugs were their degradation within body fluids full of nucleases, the potential to trigger innate immune nucleic acid sen‐ sors and, the most difficult, their delivery across the cell membrane into the cytosol (and also into the nucleus for some applications)





中文字典-英文字典  2005-2009